in my opinion, ASP is microsoft's latest web technology, so it is possible to integrated it with other microsoft technology like microsoft access. and i've tried to integrate ASP and ACCESS and works. so back to my opinion "it is surely possible that ASP nuke work with Access database". ^_^
In my opinion, Access is not suitable for the high transaction that ASP Nuke creates. At least not in the sense that a true web portal uses. If you were to use ASP Nuke for a small community such as exclusive use by a small project team (~10 people), then Access may be feasible.